Enterprise DNA does change. It is difficult but companies transform successfully all the time. Wells Fargo started as a stage coach company. Now it is in financial services. IBM owned 90 percent of the computer hardware industry. Now it owns virtually none.
Unlike humans, companies can adapt their DNA. They do it by changing who they hire and the culture that those people develop. Google today has a process that makes them very good at search and simultaneously not so good at social media.
Of all the bungles that Google has yet made in social media, the largest was not in Buzz or Wave or the shrinking Blogger franchise. It was in the fact that Ev Williams and Biz Stone worked together at Google at the same time. For these two to develop Twitter however, they had to leave the company and start all over on their own.
If Ev and Biz had been encouraged to futz around on their own, then share this Twitter thing with a few friends, who then shared it with a few friends, history may have been different.
But rewriting history is only a game. All you can glean by looking backwards is wisdom. And if failures make you wiser, as Vinod Khosla says, then Google should be the wisest of all companies when it comes to social media. Either that, or the company is destined to be like Sisyphus, the guy in Greek legend who kept pushing the rock up the mountain only to have the rock rolled back down and him having to repeat and repeat.
If Google does not show some of this wisdom soon, it may start feel its strength sap. It could lose the clout and credibility it enjoys today. It will become a less interesting company. Fewer brilliant technologists may wish to join.